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<i>Bulbophyllum emarginatum<_i> (Finet) J. J. Smith

" in MedChemExpress (MCE) Product Catalog:

3379

Inhibitors & Agonists

8

Screening Libraries

157

Fluorescent Dye

100

Biochemical Assay Reagents

295

Peptides

55

MCE Kits

52

Inhibitory Antibodies

566

Natural
Products

448

Recombinant Proteins

120

Isotope-Labeled Compounds

353

Antibodies

47

Click Chemistry

180

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-107721
    (±)-J-113397

    		Opioid Receptor Neurological Disease
    (±)-J-113397 is a potent and selective non-peptidyl ORL1 receptor antagonist with a Ki of 1.8 nM for cloned human ORL1. J-113397 inhibited nociceptin/orphanin FQ-stimulated GTPγS binding to CHO cells expressing ORL1 with an IC50 value of 5.3 nM. J-113397 can be used for researching the physiological roles of nociceptin/orphanin FQ .
    (±)-J-113397
  • HY-155172
    ZX-J-19j

    		Cyclophilin Cancer
    ZX-J-19j (Compound ZX-J-19j) is a cyclophilin J inhibitor. ZX-J-19j showes potent antitumor activity .
    ZX-J-19j
  • HY-163429
    J-1149

    		TGF-β Receptor p38 MAPK Inflammation/Immunology Cancer
    J-1149 is a potent ALK5 inhibitor, with an IC50 value of 0.017 μM. J-1149 also shows weak p38α MAP kinase inhibitory activity, with an IC50 value of 0.435 μM. J-1149 can be used for liver fibrosis research .
    J-1149
  • HY-19301
    J 104871

    J-104135

    		 Farnesyl Transferase Cancer
    J 104871 (J-104135) is a farnesyl pyrophosphate (FPP)-competitive farnesyltransferase (FTase) inhibitor. J 104871 inhibits rat brain FTase with an IC50 of 3.9 nM in the presence of farnesyl pyrophosphate (FPP) .
    J 104871
  • HY-P10951
    (R)-Zadavotide guraxetan

    (R)-PSMA I&T; (R)-PNT-2002

    		 PSMA Cancer
    Zadavotide guraxetan (PSMA I&T; PNT-2002) is a prostate-specific membrane antigen (PSMA) inhibitor. Zadavotide guraxetan has antitumor activity and can be used in prostate cancer-targeted research .
    (R)-Zadavotide guraxetan
  • HY-P2424
    Cholecystokinin-J

    CCK-J

    		 Calcium Channel Others
    Cholecystokinin-J (CCK-J), a cholecystokinin, stimulates Ca 2+ release .
    Cholecystokinin-J
  • HY-W781976
    Spinetoram J

    XDE-175-J

    		 Insecticide Infection
    Spinetoram J (XDE-175-J) is the major component of Spinetoram. Spinetoram is a green, highly effective and broad-spectrum insecticide, which is friendly to the environment, humans and animals, and degradable .
    Spinetoram J
  • HY-145855
    J-1063

    		TGF-β Receptor Inflammation/Immunology
    J-1063 is a potent, selective and orally active ALK5 inhibitor with an IC50 of 0.039 µM. J-1063 shows anti-fibrotic effect by the inhibition of inflammatory infiltration, collagen deposition, and hepatocytes necrosis. J-1063 has the potential for the research of liver fibrosis .
    J-1063
  • HY-129826
    J-104129

    		mAChR Others
    J-104129 is a selective and orally active muscarinic M3 receptor antagonist (Ki = 4.2 nM). J-104129 is effective in promoting bronchodilation .
    J-104129
  • HY-107653
    J 104129 fumarate

    		mAChR Neurological Disease
    J 104129 fumarate is a selective and orally active muscarinic M3 antagonist with Ki values of 4.2 nM and 490 nM for M3 and M2, respectively. J 104129 fumarate antagonized ACh-induced bronchoconstriction. J 104129 fumarate has the potential for the research of obstructive airway disease .
    J 104129 fumarate
  • HY-149403
    J-1048

    		Anaplastic lymphoma kinase (ALK) Others
    J-1048 is an activin receptor-like kinase 5 (ALK5) inhibitor. J-1048 can inhibit TAA-induced liver fibrosis in mice by explicitly blocking the TGF-β/Smad signaling pathway .
    J-1048
  • HY-114072A
    (S,S)-J-113397

    		Opioid Receptor Neurological Disease
    (S,S)-J-113397 is an isomer of J-113397 (HY-114072). J-113397 is an Opioid Receptor antagonist .
    (S,S)-J-113397
  • HY-116720
    J 2922

    		Biochemical Assay Reagents Endocrinology
    J 2922 is a biochemical agent. J 2922 affects egg hatching and ovarian development in the fall fly (Musca domestica), manifesting as ovarian atrophy and the absence of respiratory columns within the eggs. J 2922-induced female sterility in the fall fly is reversible, with fertility restored during the third gonotrophic cycle .
    J 2922
  • HY-118809
    J 2931

    NSC 321569; J 2532

    		 Drug Derivative Others
    J 2931 is an active compound.
    J 2931
  • HY-110216
    5J-4

    		CRAC Channel Inflammation/Immunology
    5J-4 is a potent CRAC inhibitor. 5J-4 decreases the numbers of infiltrated mononuclear cell into the CNS, and significantly decreases the population of infiltrated CD4+ population. 5J-4 reduces the symptoms and delayed the onset of EAE (experimental autoimmune encephalomyelitis) in mouse model of inflammation .
    5J-4
  • HY-103360
    J-113863
    3 Publications Verification

    		 CCR Inflammation/Immunology
    J-113863 is a potent and selective CCR1 antagonist with IC50 values of 0.9 nM and 5.8 nM for human and mouse CCR1 receptors, respectively. J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive against CCR2, CCR4 and CCR5, as well as the LTB4 or TNF-α receptors. Anti-inflammatory effect .
    J-113863
  • HY-126873
    Nikkomycin J

    		Drug Derivative Others
    Nikkomycin J is an active compound. Nikkomycin J can be used for various researches .
    Nikkomycin J
  • HY-147648
    Glyoxalase I inhibitor 6
    1 Publications Verification

    		 Glyoxalase (GLO) Cancer
    Glyoxalase I inhibitor 6 (Compound 9j) is a glyoxalase I (Glo-I) inhibitor with an IC50 of 1.13 μM. Glyoxalase I inhibitor 6 can be used as anticancer agent with low toxicity .
    Glyoxalase I inhibitor 6
  • HY-149714
    J6-3

    		ICMT Cancer
    J6-3 is an inhibitor of ICMT with an IC50 of 0.6 μM and has anticancer activity. J6-3 inhibits MDA-MB231 cells with an IC50 of 3.4 μM .
    J6-3
  • HY-13779A
    J147

    		Monoamine Oxidase Dopamine Transporter Neurological Disease
    J147 is an exceptionally potent, orally active, neuroprotective agent for cognitive enhancement. J147 can pass the blood brain barrier (BBB). J147 can inhibit monoamine oxidase B (MAO B) and the dopamine transporter. J147 plays an impotant role in Alzheimer’s disease (AD) .
    J147
  • HY-N15695
    Giganteoside J'

    		Others Others
    Giganteoside J' is a triterpenoid saponin. Giganteoside J' is found in m the roots and flowers of C. kotschyi .
    Giganteoside J'
  • HY-111615
    J-2156

    		Somatostatin Receptor Neurological Disease
    J-2156 is a high potent, selective somatostatin receptor type 4 (SST4 receptor) agonist with IC50s of 0.05 nM and 0.07 nM for human and rat SST4 receptors, respectively. J-2156 is used for the relief of mechanical allodynia and mechanical hyperalgesia in the ipsilateral hindpaws in rats .
    J-2156
  • HY-155699
    J27644

    		HDAC Inflammation/Immunology
    J27644 is a potent HDAC inhibitor. J27644 mitigates TGF-β-induced pulmonary fibrosis .
    J27644
  • HY-N15520
    Moracin J

    		Others Others
    Moracin J is found in the leaves of Cassia fistula. Moracin J is a derivative of the benzofuran compound Moracin .
    Moracin J
  • HY-N14365
    Sannamycin J

    		Bacterial Infection
    Sannamycin J is an aminoglycoside antibiotic. Sannamycin J can be found in Streptomyces sannanensis sp. KC-7038. Sannamycin J has weak antibacterial activity against Gram-positive bacteria and Gram-negative bacteria .
    Sannamycin J
  • HY-122021
    J-115814

    		Neuropeptide Y Receptor Neurological Disease
    J-115814 is a potent and selective neuropeptide Y1 antagonist with Ki values of 1.4, 1.8, 1.9, >10000, 620, 6000, >10000 nM for hY1, rY1, mY1, hY2, hY4, hY5, mY6, respectively. J-115814 inhibits feeding behaviors .
    J-115814
  • HY-N13315
    Otophylloside J

    		Others Neurological Disease
    Otophylloside J is a pregnane glycosides isolated from the roots of Cynanchum otophyllum. Otophylloside J can be used in epilepsy research .
    Otophylloside J
  • HY-N12137
    Glycoside St-J

    		Others Cancer
    Glycoside St-J (Compound 2) is a triterpenoid saponin. Glycoside St-J has antitumor activity and inhibits HeLa cell proliferation. Glycoside St-J Isolates from natural Anemone flaccida. Glycoside St-J can be used in the development of new anticancer agents .
    Glycoside St-J
  • HY-15648H
    GSK-J5 hydrochloride

    		Histone Demethylase Parasite Cancer
    GSK-J5 hydrochloride is a cell-permeable?ester derivative of?GSK J2 (HY-15648A), inactive. GSK-J5 hydrochloride is also an?isomer of GSK-J4 (HY-15648B) and often used as a negative group .
    GSK-J5 hydrochloride
  • HY-119550
    J1075

    		HDAC Parasite Infection
    J1075 is a selective Schistosoma mansoni HDAC8 inhibitor (with decreased affinity for human HDAC8). J1075 can induce apoptosis (Apoptosis) and death in schistosome cells. J1075 holds research value in the field of anti-parasitic agents .
    J1075
  • HY-N9005
    Dysolenticin J

    		Others Cardiovascular Disease
    Dysolenticin J has potent vasodilative effects on aortic rings. Dysolenticin J is an alkaloid that can be isolated from Dysoxylum lenticellatum .
    Dysolenticin J
  • HY-157269
    J10-1

    		Others Inflammation/Immunology
    J10-1 is a hapten. J10-1 promotes peptide exchange of all DR alleles (DR1, DR2, DR4 (DRB1*0401)) and promotes peptide binding to MHC II, which can be used in the study of immune regulation .
    J10-1
  • HY-N14001
    Naamidine J

    		TNF Receptor Interleukin Related Arginase PD-1/PD-L1 Inflammation/Immunology Cancer
    Naamidine J is an imidazole-type alkaloids discovered in a sponge. Naamidine J inhibits inflammation by binding to the protein CSE1L (KD = 5.41 μM). Namidine J significantly inhibits the expression of pro-inflammatory factors such as TNF-α, IL-1β, and IL-6, and upregulates anti-inflammatory factors such as CD206 and Arg-1. Namidine J inhibits PD-L1 and shows antitumor activity. Namidine J significantly reduces pulmonary tissue edema, inflammatory cell infiltration and cytokine storm in mice. Namidine J can be used for the research on the immune microenvironment of acute lung injury and tumors .
    Naamidine J
  • HY-116129
    BPR1J-340

    		FLT3 Apoptosis Cancer
    BPR1J-340 is a potent FLT3 inhibitor with an IC50 of ~25 nM. BPR1J-340 inhibits the phosphorylation of FLT3 and STAT5 and triggered apoptosis in FLT3-ITD + acute myeloid leukemia (AML) cells. BPR1J-340 exhibits significant anti-tumor activities .
    BPR1J-340
  • HY-N10899
    Bruceine J

    		Parasite Infection
    Bruceine J, a quassinoid, is a nature product that could be isolated from fruits of Br. jaVanica. Bruceine J has anti-Babesial activity .
    Bruceine J
  • HY-N9312
    Ganoderic acid J

    		Others Inflammation/Immunology
    Ganoderic acid J is a natural terpenoid isolated from the Fungus Ganoderma lucidum. Ganoderic acid J possesses anti-inflammatory anti-inflammatory activity .
    Ganoderic acid J
  • HY-N12812
    Tenuifoliose J

    		Others Neurological Disease
    Tenuifoliose J is a neuroprotective oligosaccharide. Tenuifoliose J protects SY5Y cells induced by corticosterone (HY-B1618) .
    Tenuifoliose J
  • HY-113366S
    Prostaglandin J2-d4

    		Isotope-Labeled Compounds Others
    Prostaglandin J2-d4 is the deuterium labeled Prostaglandin J2 .
    Prostaglandin J2-d4
  • HY-124653
    HSP27 inhibitor J2
    5+ Cited Publications

    J2

    		 HSP Cancer
    HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition .
    HSP27 inhibitor J2
  • HY-149713
    J1-1

    		ICMT Cancer
    J1-1 is an inhibitor of ICMT with an IC50 of 1.0 μM and has anticancer activity .
    J1-1
  • HY-112255
    J9

    		Glucocorticoid Receptor Cancer
    J9 is a small molecule that reverses Dexamethasone (HY-14648) resistance in T-cell acute lymphoblastic leukemia. J9 is lethal to CUTLL1 cells only in the presence of Dexamethasone. J9 inhibits CUTLL1 cell growth with an EC50 of 28 μM in combination with Dexamethasone .
    J9
  • HY-N12720
    Cynanoside J

    		Others Cancer
    Cynanoside J is a C21 steroidal glycosides that can be obtained from Cynanchum taihangense. The IC50 values of Cynanoside J for HL-60, THP1, and Caco2 are 6.38, 5.82, and 6.76 μM, respectively. Cynanoside J can be used in cancer research .
    Cynanoside J
  • HY-163535
    J208

    		HDAC DNA Methyltransferase Apoptosis Inflammation/Immunology Cancer
    J208 is a dual inhibitor for histone deacetylase (HDAC) and DNA methyltransferase (DNMT). J208 inhibits proliferation of cancer cells, as well as the migration/invasion of triple-negative breast cancer (TNBC) cells. J208 induces apoptosis, arrests the cell cycle at G0/G1 phase. J2008 activates the innate immune signalling pathway in TNBC, by inducing the expression of endogenous retroviruses (ERVs) .
    J208
  • HY-N15387
    Hericenone J

    		Drug Derivative Cancer
    Hericenone J (Compound 6) is an aromatic compound with anticancer activity, which is found in Hericium erinaceum. Hericenone J is cytotoxic and can significantly reduce the viability of HL-60 human acute promyelocytic leukemia cells with an IC50 value of 4.13 μM. Hericenone J is promising for research of leukemia .
    Hericenone J
  • HY-130468
    Leptosin J

    		Others Cancer
    Leptosin J is found in the strain of Leptosphaeria sp. OUPS-4. Leptosin J inhibits Leukemia lymphocyte P388 in culture with an ED50 of 1.25 μg/mL .
    Leptosin J
  • HY-111615A
    J-2156 TFA

    		Somatostatin Receptor Neurological Disease Inflammation/Immunology
    J-2156 TFA is a high potent, selective somatostatin receptor type 4 (SST4 receptor) agonist with IC50s of 0.05 nM and 0.07 nM for human and rat SST4 receptors, respectively. J-2156 TFA has anti-inflammatory activity and it is used for the relief of mechanical allodynia and mechanical hyperalgesia in the ipsilateral hindpaws in rats .
    J-2156 TFA
  • HY-125838
    J30-8

    		JNK Neurological Disease
    J30-8 is a potent and isoform-selective inhibitor of c-Jun N-terminal kinase 3 (JNK3) with an IC50 of 40 nM, which 2500-fold isoform selectivity against JNK1α1 and JNK2α2. J30-8 exhibits neuroprotective activity in vitro and potential for the treatment of neurodegenerative diseases .
    J30-8
  • HY-15648I
    GSK-J2 sodium

    		Histone Demethylase Cancer
    GSK-J2 sodium is the sodium form of GSK-J2 (HY-15648A). GSK-J2 is an isomer of GSK-J1, and does not have any specific activity. GSK-J1 (HY-15648) is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A .
    GSK-J2 sodium
  • HY-N9670
    Epimedonin J

    		Others Others
    Epimedonin J is a natural product .
    Epimedonin J
  • HY-N13575
    Gancaonin J

    		Others Others
    Gancaonin J is a natural product .
    Gancaonin J

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